| Purpose:
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To document cellular thickness changes in the cornea using the confocal microscope on a group of neophytes wearing the PureVision lens in one eye and the Acuvue 2 lens on the contralateral eye. |
| Method: |
| In-vivo slit-scanning real-time confocal microscopy and ultrasound pachometry were performed on both eyes of 23 subjects (11 M, 12 F, age 23 ± 3 years) at the initial visit (baseline), after three and six months of lens wear, and after one week during which no contact lens were worn. Data were analysed using Super ANOVA 1.11 (Abacus Concepts Inc). |
| Results: |
| Anterior keratocyte density did not change between the four visits (F=0.9, p=0.46) and was no different for the two lenses (F=1.6, p=0.21). Posterior keratocyte density was similar for the two lenses at the different visits (F=0.1, p=0.82), but there were differences between the visits (F=18.44, p=0.0001). Cell counts at the three month, six-month and final visit were found to be lower than at the initial visit (Post hoc analysis). No differences were found between the two lenses (F=0.1, p=0.81) or the four study visits (F=1.4, p=0.26) for the endothelial cell density. Corneal thickness was similar for the two lenses at the initial and final visits, but was greater for the Acuvue 2 lens at the six month visit (F=4.3, p=0.02). |
| Conclusions: |
| Corneal thickness changes were consistent with the relative oxygen performances of the two lens types. This study demonstrates a reduction in posterior stromal keratocyte density with extended wear contact lenses. This reduction does not seem to be related to the oxygen performance of the lens, and may instead be related to other factors such as the mechanical presence of the lens. |
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